What seems a very difficult passage - Genesis 3:14-24

This passage introduces the question where did all these others come from. John Gill has a simple answer, though the Bible leaves this unspoken...so we really are only speculating. But perhaps this is part of our faith of believing.

and it shall come to pass, that everyone that findeth me shall slay me; that is, some one, the first that should meet him, for he could be slain but by one; so odious he knew he should be to everyone, being under such marks of the divine displeasure, that his life would be in danger by whomsoever he should be found: and this being near an hundred and thirty years after the creation of man, see Gen 4:25 Gen 5:3 there might in this time be a large number of men on earth; Adam and Eve procreating children immediately after the fall, and very probably many more besides Cain and Abel, and those very fruitful, bringing many at a birth and often, and few or none dying, the increase must be very great; and we read quickly after this of a city being built, Gen 4:17. Cain seems to be more afraid of a corporeal death than to have any concern about his soul, and the eternal welfare of it, or to be in dread and fear of an eternal death, or wrath to come; though some think the words should be rendered in a prayer (x), "let it be that anyone that findeth me may kill me"; being weary of life under the horrors of a guilty conscience.

So Gill is refering to this period of undocumented time gap, of which the Bible does not speak.

This could have been either before or after their being sent out of the garden.

Gen 3:23  Therefore the LORD God sent him forth from the garden of Eden, to till the ground from whence he was taken.

Gen 3:24  So he drove out the man; and he placed at the east of the garden of Eden Cherubims, and a flaming sword which turned every way, to keep the way of the tree of life.

But do note that the command to be fruitful existed from the beginning.

Gen 1:27  So God created man in his own image, in the image of God created he him; male and female created he them.

Gen 1:28  And God blessed them, and God said unto them, Be fruitful, and multiply, and replenish the earth, and subdue it: and have dominion over the fish of the sea, and over the fowl of the air, and over every living thing that moveth upon the earth.

So we don't know the details until...

Cain and Abel

Gen 4:1  And Adam knew Eve his wife; and she conceived, and bare Cain, and said, I have gotten a man from the LORD.

Gen 4:2  And she again bare his brother Abel. And Abel was a keeper of sheep, but Cain was a tiller of the ground.

Gen 4:3  And in process of time it came to pass, that Cain brought of the fruit of the ground an offering unto the LORD.

Gen 4:14  Behold, thou hast driven me out this day from the face of the earth; and from thy face shall I be hid; and I shall be a fugitive and a vagabond in the earth; and it shall come to pass, that every one that findeth me shall slay me.

Gen 4:15  And the LORD said unto him, Therefore whosoever slayeth Cain, vengeance shall be taken on him sevenfold. And the LORD set a mark upon Cain, lest any finding him should kill him.

Gen 4:16  And Cain went out from the presence of the LORD, and dwelt in the land of Nod, on the east of Eden.

Gen 4:17  And Cain knew his wife; and she conceived, and bare Enoch: and he builded a city, and called the name of the city, after the name of his son, Enoch.

Gen 4:18  And unto Enoch was born Irad: and Irad begat Mehujael: and Mehujael begat Methusael: and Methusael begat Lamech.

Gen 4:19  And Lamech took unto him two wives: the name of the one was Adah, and the name of the other Zillah.

Gen 4:20  And Adah bare Jabal: he was the father of such as dwell in tents, and of such as havecattle.

Gen 4:21  And his brother's name was Jubal: he was the father of all such as handle the harp and organ.

Gen 4:22  And Zillah, she also bare Tubalcain, an instructer of every artificer in brass and iron: and the sister of Tubalcain was Naamah.

Gen 4:23  And Lamech said unto his wives, Adah and Zillah, Hear my voice; ye wives of Lamech, hearken unto my speech: for I have slain a man to my wounding, and a young man to my hurt.

Gen 4:24  If Cain shall be avenged sevenfold, truly Lamech seventy and sevenfold.

Gen 4:25  And Adam knew his wife again; and she bare a son, and called his name Seth: For God, said she, hath appointed me another seed instead of Abel, whom Cain slew.